Strasbourg France - 2012. Located at the border with Germany in the historic region of Alsace, Strasbourg is one of the de facto four main capitals of the European Union (alongside Brussels, Luxembourg and Frankfurt), as it is the seat of several European institutions, such as the European Parliament, the Eurocorps and the European Ombudsman of the European Union. An organization separate from the European Union, the Council of Europe (with its European Court of Human Rights, its European Directorate for the Quality of Medicines.